We develop “Precision Human Digital-Twins Sytem (Precision hDTS) (aka Live Digital-Twins)” to detect early signs of molecular, cellular, organ, inter-organ dysfunctions inside our body and repair such conditions at the earliest time point to prevent disease development, all in “real-time” and also on the basis of unique multi-modal features of individuals. Based on the deep understanding of molecular, cellular, organ and inter-organ mechanisms and their individual uniqueness of disease development, we develop requisite modules for the Precision hDTS and provide this system to each of our stakeholders. This system provides not only the earliest detection system of diseases, but together with preventions and treatments, all as an integrated system precisely customized to individuals. With the Precision hDTS (itself and also its individual modules), we contribute to the realization of the healthy longevity of all diverse people in our society.