We develop “Precision Human Digital-Twins Sytem (Precision hDTS) and its composite modules. The Precision hDTS consists of four modules: 1) Sensor nano-machines, 2) Therapeutic nano-machines, 3) Digital-twin of oneself, 4) Milli-scale implantable device. The sensor nano-machines detect, in real-time, dysregulation of molecules and cells inside oneself, such as sugar levels, tumorigenesis, virus infection, etc.. The therapeutic nano-machines provides therapeutic agents to prevent and/or treat the dysregulation detected by the sensor nano-machines. The digital-twin of oneself is the mathematical model of oneself that are build and renewed in real-time according the information detected by the senor nano-machines with its output capability of the present and the future state of the body (such as diseases) and also the best suitable therapeutics for the oneself. The milli-scale implantable device is a relay point that mediates and integrates the cross-talk information among the modules 1), 2) and 3) in real-time. We provides our stakeholders with the Precision hDTS and its consisting modules, and also its underlying technologies and sensor/therapeutic targets.